Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Porta, S; Klingenberg, HG; Egger, G; Sattelberger, R; Sadjak, T.
Comparison of adrenaline-induced hyper- and hypoglycaemia by histological and biochemical investigation.
EXP PATHOL. 1983; 23(2): 115-120.
Doi: 10.1016/S0232-1513(83)80048-6
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- Führende Autor*innen der Med Uni Graz
- Porta Sepp
- Co-Autor*innen der Med Uni Graz
- Sadjak Anton
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- Abstract:
- Chronic treatment of rats by subcutaneously implanted A-depot capsules lead through a ca. 12 h hyperglycaemia to hypoglycaemia at 18 h p.o. SDH and G-6-Phase activities in the liver were compared during hyper- and hypoglycaemia using both histochemical and biochemical methods. The results show high triglyceride-contents, lack of glycogen and high G-6-Pase activities in the livers of animals during both hyper- and hypoglycaemia. Striking differences were found concerning SDH-activities: While biochemical measurements show enhanced activities during hyperglycaemia, hypoglycaemic values remain in the "normal" range. Nevertheless histochemical investigations show an amazing re-distribution of SDH-activities from the periportal areas towards the lobule centre. Therefore we think, that biochemical and histochemical methods should be combined to unveil such pseudonormalities. Further, this re-distribution shows the ability of the liver to cope with damage by shifting important processes away from fat-infiltrated areas.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Epinephrine -
- Female -
- Glucosephosphate Dehydrogenase - metabolism
- Hyperglycemia - chemically induced
- Hypoglycemia - chemically induced
- Liver - enzymology
- Male - enzymology
- Rats - enzymology
- Rats, Inbred Strains - enzymology
- Succinate Dehydrogenase - metabolism