Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weger, W; Hofer, A; Stanger, O; Wolf, P; El-Shabrawi, Y; Renner, W; Kerl, H; Salmhofer, W.
The methylenetetrahydrofolate reductase 677C>T gene polymorphism is not associated with chronic plaque psoriasis.
Exp Dermatol. 2008; 17(9): 748-751.
Doi: 10.1111/j.1600-0625.2008.00713.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Weger Wolfgang
- Co-Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Hofer Angelika
- Kerl Helmut
- Renner Wilfried
- Salmhofer Wolfgang
- Wolf Peter
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- Abstract:
- BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is involved in the formation of methyl donors, which contribute to DNA methylation. DNA methylation is an essential epigenetic feature playing a critical role in gene regulation and cellular differentiation. In addition, MTHFR activity affects plasma homocysteine levels. A functional polymorphism in the MTHFR gene (677C>T, rs1801133) leading to reduced enzyme activity has been associated with chronic plaque psoriasis in a Chinese population. This finding, however, has not yet been either confirmed or refuted in other populations. The purpose of the present study was to investigate a hypothesized association between the MTHFR 677C>T polymorphism and the presence of chronic plaque psoriasis in a Caucasian population. METHODS: Genotypes for the MTHFR 677C>T polymorphism were determined in 310 patients and 247 control subjects. In a subgroup of 33 patients and 33 sex- and age-matched control subjects, fasting plasma homocysteine concentrations were determined by high-performance liquid chromatography and immunological assays were used for the measurement of folate and vitamin B(12). RESULTS: Prevalence of the homozygous MTHFR 677TT genotype did not significantly differ between patients and controls (15.2% vs 11.7%, P = 0.24). Mean plasma homocysteine concentrations were significantly higher in psoriasis patients than among control subjects (13.5 +/- 5.3 micromol/l vs 11.0 +/- 2.2 micromol/l, P = 0.026). No significant differences between either mean plasma folate or vitamin B(12) concentrations were observed between both groups. CONCLUSION: Our data suggest that the MTHFR 677C>T gene polymorphism is not associated with chronic plaque psoriasis among Caucasians.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Austria -
- Case-Control Studies -
- European Continental Ancestry Group -
- Female -
- Folic Acid - blood
- Homocysteine - blood
- Humans -
- Male -
- Methylenetetrahydrofolate Reductase (NADPH2) - genetics
- Middle Aged -
- Polymorphism, Single Nucleotide -
- Psoriasis - genetics
- Vitamin B 12 - blood
- Find related publications in this database (Keywords)
- chronic plaque psoriasis
- folate
- homocysteine
- MTHFR 677C > T gene polymorphism
- vitamin