Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stolte, T; Hosel, V; Mueller, J; Speicher, M.
Modeling clonal expansion from M-FISH experiments.
J COMPUT BIOLOGY. 2008; 15(2): 221-230.
Doi: 10.1089/cmb.2007.0076
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Speicher Michael
- Tieber Ida
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- Abstract:
- A population genetic model is used to describe dynamical aspects of chromosomal abberations observed in M-FISH experiments. Linear differential equations model the evolution of relative frequencies of mutations. The unknown parameters involved are estimated by maximum likelihood methods. We propose a scoring system to select the most important mutations. In order to reduce the number of parameters and computation time, only the highest ranked mutations are considered. First applications to M-FISH data show rather promising results.
- Find related publications in this database (using NLM MeSH Indexing)
- Chromosome Aberrations -
- Genetics, Population -
- In Situ Hybridization, Fluorescence -
- Likelihood Functions -
- Mathematics -
- Models, Genetic -
- Mutation -
- Find related publications in this database (Keywords)
- carcinogenesis
- chromosome abberation
- dynamical model
- M-FISH
- population genetics