Medizinische Universität Graz - Research portal
Selected Publication:
Hödl, S.
Side-effects of beta-receptor blockaders on the skin
Z Hautkr. 1983; 58(1):17-28
(- Case Report)
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- Leading authors Med Uni Graz
- Hoedl Stefan
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- Abstract:
- Cutaneous side effects due to beta-adrenoreceptor-blocking agents are clinically polymorphous. Apparently they appear after several months of continuous therapy. Atypical psoriasiform, lichen planus-like, and eczematous "chronic" rashes are mainly observed. The histological picture usually corresponds to a lichenoid drug reaction. More rarely the so-called pseudo-lupus erythematodes-syndrome is found, which cannot be differentiated from the "idiopathic" disease. Noteworthy extracutaneous manifestations are fibrosing processes, which may be irreversible. Pathogenetically, a delayed hypersensitivity reaction, and an action on the epidermal chalone system (epinephrine-adenylcyclase-c-AMP-complex) may be assumed. Consequently, continuous observation of the skin and mucous membranes is necessary, and medication should be withdrawn if cutaneous side-effects appear.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic beta-Antagonists - adverse effects
- Exanthema - chemically induced
- Humans - chemically induced
- Lichen Planus - chemically induced
- Male - chemically induced
- Middle Aged - chemically induced
- Psoriasis - chemically induced
- Skin Diseases - chemically induced