Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hausleiter, HJ; Achtert, G; Khan, MA; Kukovetz, WR; Beubler, E.
Pharmacokinetics and biotransformation of N-propylajmaline hydrogen tartrate in man
EUR J DRUG METAB PHARM. 1982; 7(4): 329-339.
Doi: 10.1007/BF03189637
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- Co-Autor*innen der Med Uni Graz
- Beubler Eckhard
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- Abstract:
- 10 and 20 mg of N-Propyl-ajmalin-hydrogentartrate (N-PAB, Neo-Gilurytmal) were administered i.v. and orally respectively to healthy volunteers. In the study 14C-labelled N-PAB was used. The pharmacokinetics and the metabolic behaviour was examined. A fast and complete absorption of the compound could be observed. The bioavailability was 78%. The terminal plasma elimination half-life (beta-phase) was in the range of 4 to 6 hours. A total of 33% of the administered radioactivity was excreted via the kidney. 35 to 48% of the radioactivity found in urine was unchanged N-PAB. The excretion-kinetics of the three main metabolites as well as of the parent compound were determined. The possible presence of non-metabolizers is suggested.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
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- Biotransformation - analogs and derivatives
- Blood Proteins - metabolism
- Humans - metabolism
- Kinetics - metabolism
- Male - metabolism
- Models, Biological - metabolism
- Prajmaline - blood
- Protein Binding - blood