Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gao, Y; Goswami, N; Grasser, E; Rössler, A; Stöger, E; Schwaberger, G; Hinghofer-Szalkay, HG.
Radix astragali and orthostatic response: a double-masked crossover study.
Aviat Space Environ Med. 2008; 79(2): 94-98.
Doi: 10.3357/ASEM.2193.2008
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hinghofer-Szalkay Helmut
- Co-Autor*innen der Med Uni Graz
- Goswami Nandu
- Rössler Andreas
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- Abstract:
- AIM: Recent results from animal experiments have shown that radix astragali (RA), a traditional Chinese herbal tonic, alleviates muscle atrophy under simulated weightlessness conditions, rendering RA a candidate for human use as a countermeasure against muscular atrophy. Possible cardiovascular side effects have not yet been investigated. We analyzed the effects of RA on the orthostatic stability of healthy men. METHODS: There were 10 test subjects who were assigned to a double-blinded, randomized crossover design using RA or placebo (PL) for 14 d each, respectively. Test runs were separated by a 14-d 'washout' interval. At the beginning and the end of every 14-d test run, graded orthostatic stress (GOS) consisting of head-up tilt (HUT) combined with lower body negative pressure (LBNP) was used to achieve a presyncopal endpoint. Orthostatic effects on cardiac and vascular function were continuously monitored. RESULTS: There were no significant differences between the RA vs. PL groups: mean arterial blood pressure dropped by 13 vs. 17%, pulse pressure 46 vs. 35%, heart rate increased 108 vs. 117%, and stroke volume index decreased 54 vs. 49% from supine control to presyncope. Neither did RA influence standing time compared to PL (18 +/- 7 vs. 17 +/- 6 min), nor did progression from the first to the fourth trial (15 +/- 6 to 18 +/- 7 min). CONCLUSION: RA does not influence resting cardiovascular variables and orthostatic capacity in humans. It can be expected that human studies of RA's musculo-skeletal countermeasure potential will not be compromised by any cardiovascular side effects at the dosage employed in this study.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Pressure - drug effects
- Cross-Over Studies -
- Double-Blind Method -
- Drugs, Chinese Herbal - pharmacology
- Heart Rate - drug effects
- Humans -
- Hypotension, Orthostatic -
- Male -
- Muscular Atrophy - drug therapy
- Neuromuscular Agents - pharmacology
- Syncope - physiopathology
- Tilt-Table Test -
- Weightlessness - adverse effects
- Weightlessness Countermeasures -
- Weightlessness Simulation - methods