Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Seewann, HL; Tilz, GP; Becker, H; Lehnert, M.
IgD-paraproteinemia in lymphoplasmacytoid immunocytoma
DEUT MED WOCHENSCHR. 1982; 107(46): 1763-1766.
Doi: 10.1055/s-2008-1070203
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Tilz Gernot
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- Abstract:
- Laminectomy was performed in a 54-year-old patient who had a hemicauda syndrome. An epidural tumour, extending into the spongiosa of the third lumbar vertebra was found. Histologically it was a lymphoplasmacytoid lymphoma. Subsequent haematological investigation revealed a multilocular involvement (stage IV) and paraproteinaemia of the IgD-kappa-type. There was no Bence-Jones protein in the urine. After irradiation of the affected lumbar vertebra the patient was treated with a combination of chlorambucil and prednisone, later on with COP and VMCP regimens. A rapid downhill course set in 16 months after diagnosis and the patient died from intracerebral expansion of the immunocytoma. The clinical diagnosis was confirmed at autopsy. The generalized lymphoplasmacytoid immunocytoma contained evidence of terminal transformation into the polymorph subtype.
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