Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Barthó, L; Holzer, P; Donnerer, J; Lembeck, F.
Evidence for the involvement of substance P in the atropine-resistant peristalsis of the guinea-pig ileum.
Neurosci Lett. 1982; 32(1):69-74
Doi: 10.1016/0304-3940(82)90231-2
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- Co-Autor*innen der Med Uni Graz
- Donnerer Josef
- Holzer Peter
- Lembeck Fred
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- Abstract:
- In the isolated, vascularly perfused guinea-pig ileum, peristalsis could be induced by raising the intraluminal pressure in the presence of atropine. Atropine-resistant peristalsis was greatly inhibited or abolished by the substance P antagonist (D-Pro2, D-Trp7.9)-substance P, substance P desensitization, hexamethonium and by the enkephalin analogue FK 33-824. It is concluded that substance P neurones of the intestine play an important role in the atropine-resistant peristalsis of the guinea-pig ileum.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Atropine - pharmacology
- D-Ala(2),MePhe(4),Met(0)-ol-enkephalin - pharmacology
- Enkephalins - pharmacology
- Gastrointestinal Motility - drug effects
- Guinea Pigs - drug effects
- Ileum - drug effects
- Neurons - drug effects
- Peristalsis - drug effects
- Pressure - drug effects
- Substance P - analogs and derivatives