Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kaddu, S; Wolf, I; Horn, M; Kerl, H.
Epithelioid sarcoma with angiomatoid features: report of an unusual case arising in an elderly patient within a burn scar.
J Cutan Pathol. 2008; 35(3):324-328
Doi: 10.1111/j.1600-0560.2007.00802.x
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- Führende Autor*innen der Med Uni Graz
- Kaddu Steven
- Co-Autor*innen der Med Uni Graz
- Horn Michael
- Kerl Helmut
- Wolf Ingrid
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- Abstract:
- Epithelioid sarcoma (ES) is a rare, aggressive soft tissue tumor with a characteristic predilection for adolescents and young adults, and a tendency to occur on distal extremities. We report a case of ES arising in an 80-year-old woman within a burn scar that histopathologically showed unusual 'angiomatoid' features. The patient presented initially with a solitary nodule on her right wrist arising at the site of a burn scar. Histopathologically, the tumor was composed of a proliferation of relatively bland, epithelioid and spindle cells focally arranged in a nodular pattern around areas of 'geographic' necrosis. In addition, there were prominent foci of hemorrhage and blood-filled spaces as well as tumor cells with intracytoplasmic vacuoles, features suggestive of an angiomatous process. Immunohistochemistry showed positivity of tumor cells for cytokeratins and epithelial membrane antigen (EMA) whereas all vascular markers tested were negative. The overall histopathologic features were consistent with a diagnosis of ES. Follow up showed multiple recurrences arising proximally along the right upper extremity. Our case underlines the clinical and histopathological heterogeneity of ES, emphasizing the unusual occurrence of ES with 'angiomatoid' features in the elderly. In this uncommon setting, this tumor should be especially distinguished from epithelioid hemangioendothelioma and epithelioid angiosarcoma. The significance of development of ES on a healed burn scar is uncertain, but may suggest a possible causal relationship.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged, 80 and over -
- Angiomatosis - pathology
- Burns - complications Burns - pathology
- Cicatrix - complications Cicatrix - pathology
- Female -
- Humans -
- Keratins - analysis
- Mucin-1 - analysis
- Neoplasm Recurrence, Local -
- Sarcoma - chemistry Sarcoma - complications Sarcoma - pathology
- Soft Tissue Neoplasms - chemistry Soft Tissue Neoplasms - complications Soft Tissue Neoplasms - pathology
- Tumor Markers, Biological - analysis
- Wrist -