Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Moliterno, DJ; Lange, RA; Gerard, RD; Willard, JE; Lackner, C; Hillis, LD.
Influence of intranasal cocaine on plasma constituents associated with endogenous thrombosis and thrombolysis.
Am J Med. 1994; 96(6):492-496
Doi: 10.1016/0002-9343(94)90087-6
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Lackner Karoline
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- Abstract:
- PURPOSE: As cocaine abuse has become widespread, catastrophic cocaine-associated cardiovascular events have been noted with increasing frequency. Although these incidents are thought to be caused by drug-induced vasoconstriction and/or arterial thrombosis, the influence of cocaine on the plasma constituents involved in endogenous thrombosis and thrombolysis has not been characterized. PATIENTS AND METHODS: In 22 patients (8 men, 14 women, ages 32 to 62 years) undergoing cardiac catheterization, blood samples were procured before and 15 minutes after the administration of intranasal saline (n = 8, controls) or cocaine, 2 mg/kg (n = 14), and the plasma concentrations of fibrinogen, plasminogen, and lipoprotein(a), as well as tissue plasminogen activator activity and plasminogen activator inhibitor (PAI-1) activity, were measured. RESULTS: No variable changed with the use of intranasal saline, whereas the use of cocaine resulted in an increase in PAI-1 activity (0.48 + 0.06 [mean + SD] nmol/L at baseline, 0.53 + 0.05 nmol/L after cocaine, P = 0.011). CONCLUSION: Intranasal cocaine administration is associated with an increase in plasma PAI-1 activity. This may be important in recreational users of cocaine who experience vascular thrombosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Intranasal -
- Adult -
- Blood Coagulation - drug effects
- Blood Coagulation Factors - metabolism
- Chi-Square Distribution - metabolism
- Cocaine - administration and dosage
- Female - administration and dosage
- Fibrinogen - metabolism
- Humans - metabolism
- Lipoprotein(a) - blood
- Male - blood
- Middle Aged - blood
- Plasminogen - metabolism
- Plasminogen Activator Inhibitor 1 - blood
- Tissue Plasminogen Activator - blood