Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ramirez, LC; Arauz-Pacheco, C; Lackner, C; Albright, G; Adams, BV; Raskin, P.
Lipoprotein (a) levels in diabetes mellitus: relationship to metabolic control.
Ann Intern Med. 1992; 117(1):42-47
Doi: 10.7326/0003-4819-117-1-42
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- Co-Autor*innen der Med Uni Graz
- Lackner Karoline
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- Abstract:
- OBJECTIVE: To determine the influence of diabetes control on serum lipoprotein (a) concentrations. SETTING: Diabetes clinic of a large metropolitan public hospital, with primary- and secondary-care patients. DESIGN: A cross-sectional study. Comparisons of lipoprotein (a) concentrations were made between a normal control group, a group of diabetic patients with glycated hemoglobin (HbA1c) less than 8.0%, and a group of diabetic patients with HbA1c of 8.0% or higher. PATIENTS: Ninety-five normal controls and 93 diabetic subjects (49 with insulin-dependent diabetes mellitus and 44 with noninsulin-dependent diabetes mellitus). RESULTS: Sixty diabetic subjects with HbA1c levels of 8.0% or higher had higher (25 mg/dL) median levels of lipoprotein (a) when compared with either 93 normal controls (8.8 mg/dL) or 33 diabetic patients with HbA1c less than 8.0% (7.5 mg/dL) (P = 0.008 and P = 0.012, respectively). A similar pattern of distribution of lipoprotein (a) levels according to degree of metabolic control was seen in patients with insulin-dependent diabetes mellitus and noninsulin-dependent diabetes mellitus. No difference in the lipoprotein (a) distribution was noted between diabetic men and women. No correlation was observed between lipoprotein (a) levels and total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels. CONCLUSION: Lipoprotein (a) levels are elevated in poorly controlled diabetic patients. Increased levels of lipoprotein (a) may be a contributing factor to the high risk for atherosclerosis observed in diabetic patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cross-Sectional Studies -
- Diabetes Mellitus - blood
- Diabetes Mellitus, Type 1 - blood
- Diabetes Mellitus, Type 2 - blood
- Female - blood
- Hemoglobin A, Glycosylated - analysis
- Humans - analysis
- Lipoprotein(a) - analysis
- Lipoproteins - blood
- Male - blood
- Middle Aged - blood
- Find related publications in this database (Keywords)
- DIABETES-MELLITUS
- ATHEROSCLEROSIS
- HEMOGLOBIN-A, GLYCOSYLATED
- LIPOPROTEINS