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Holzer, P; Lippe, IT; Barthó, L; Lembeck, F.
D-Met2, Pro5enkephalinamide and dynorphin-(1-13) inhibit the cholinergic contraction induced in the guinea-pig ileum by substance P.
EUR J PHARMACOL. 1983; 91(1): 83-88. Doi: 10.1016/0014-2999(83)90365-5
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Leading authors Med Uni Graz: Holzer Peter
Co-authors Med Uni Graz: Lembeck Fred; Lippe Irmgard Theresia
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Abstract:: In the isolated guinea-pig ileum, the sustained phase of the longitudinal contractile response to substance P is, unlike the initial peak response, mediated by stimulation of cholinergic neurons. This cholinergically mediated response to substance P was inhibited by the specific substance P antagonist, [D-Pro2,D-Trp7,9]substance P, which suggests that substance P stimulates enteric cholinergic neurons through a specific site of action. [D-Met2,Pro5]enkephalinamide and dynorphin-(1-13) also decreased whereas naloxone increased the sustained response to substance P. The results indicate that the enteric cholinergic neurons, which are stimulated by substance P, are also under the control of enkephalin and/or dynorphin neurons.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Atropine - pharmacology; Dynorphins - pharmacology; Endorphins - pharmacology; Enkephalin, Methionine - analogs and derivatives; Female - analogs and derivatives; Guinea Pigs - analogs and derivatives; Ileum - drug effects; Male - drug effects; Muscle Contraction - drug effects; Muscle, Smooth - drug effects; Naloxone - pharmacology; Parasympathetic Nervous System - drug effects; Peptide Fragments - pharmacology; Substance P - antagonists and inhibitors