Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Koestenberger, M; Cvirn, G; Nagel, B; Rosenkranz, A; Leschnik, B; Gamillscheg, A; Beitzke, A; Muntean, W.
Thrombin generation determined by calibrated automated thrombography (CAT) in pediatric patients with congenital heart disease.
Thromb Res. 2008; 122(1): 13-19.
Doi: 10.1016/j.thromres.2007.08.016
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Koestenberger Martin
- Co-Autor*innen der Med Uni Graz
- Beitzke Albrecht
- Cvirn Gerhard
- Ehammer-Rosenkranz Andrea
- Gamillscheg Andreas
- Leschnik Bettina
- Muntean Eugen
- Nagel Bert Hermann Philipp
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- Abstract:
- INTRODUCTION: Thrombin generation was studied in pediatric patients with congenital heart disease (CHD) undergoing cardiac surgery using the calibrated automated thrombography (CAT) in terms of the lag time until the onset of thrombin formation, time to thrombin peak maximum (TTP), endogenous thrombin potential (ETP), and thrombin peak height. The possible suitability to determine the coagulation status of these patients was investigated. MATERIALS AND METHODS: CAT data of 40 patients with CHD (age range from newborn to 18 years) were compared to data using standard coagulation parameters such as prothrombin (FII), antithrombin (AT), tissue factor pathway inhibitor (TFPI), prothrombin fragment 1.2 (F 1.2), thrombin-antithrombin (TAT), activated partial thromboplastin time (aPTT), and prothrombin time (PT). RESULTS: A significant positive correlation was seen between ETP and FII (p<0.01; r=0.369), as well as between peak height and F II (p<0.01; r=0.483). A significant negative correlation was seen between ETP and TFPI values (p<0.05; r=-0.225) while no significant correlation was seen between peak height and TFPI. A significant negative correlation was seen between F 1.2 generation and ETP (p<0.05; r=-0.254) and between F 1.2 generation and peak height (p<0.05; r=-0.236). No correlation was seen between AT and ETP or peak. CONCLUSIONS: Our data indicate that CAT is a good global test reflecting procoagulatory and inhibitory factors of the hemostatic system in pediatric patients with CHD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antithrombins - metabolism
- Child -
- Child, Preschool -
- Heart Defects, Congenital - blood
- Humans -
- Infant -
- Infant, Newborn -
- Kinetics -
- Partial Thromboplastin Time -
- Peptide Fragments - blood
- Prothrombin Time -
- Thrombin - biosynthesis
- Find related publications in this database (Keywords)
- calibrated automated thrombography
- thrombin generation
- endogenous thrombin potential
- prothrombin
- cardiac surgery
- congenital heart disease