Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Holzer, P; Bucsics, A; Lembeck, F.
Distribution of capsaicin-sensitive nerve fibres containing immunoreactive substance P in cutaneous and visceral tissues of the rat.
NEUROSCI LETT. 1982; 31: 253-257.
Doi: 10.1016/0304-3940(82)90029-5
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Lembeck Fred
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- Abstract:
- Treatment of newborn rats with capsaicin causes a selective and permanent degeneration of unmyelinated sensory fibres, some of which contain immunoreactive substance P (ISP). Following treatment of newborn rats with capsaicin (50 mg/kg), the ISP content was decreased by 66-75% in various skin areas and in the oral and nasal mucosae as measured at the age of 3-4 months. There was no significant depletion of ISP in the mucosa of the tongue. The ISP content of trachea, lungs, myocardium, hepatic duct, ureter and urinary bladder, was decreased by 60-84%. The ISP concentrations in stellate and mesenteric ganglia were reduced by 54 and 81%, respectively. These results indicate a widespread innervation of cutaneous and visceral tissues by sensory nerve fibers containing ISP.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bladder - innervation
- Capsaicin - pharmacology
- Fatty Acids, Unsaturated - pharmacology
- Heart - innervation
- Hepatic Duct, Common - innervation
- Lung - innervation
- Mesentery - innervation
- Mouth Mucosa - innervation
- Nerve Degeneration - drug effects
- Nerve Fibers - drug effects
- Rats - drug effects
- Rats, Inbred Strains - drug effects
- Research Support, Non-U.S. Gov't - drug effects
- Skin - innervation
- Stellate Ganglion - drug effects
- Substance P - metabolism
- Trachea - innervation
- Ureter - innervation