Medizinische Universität Graz - Research portal
Selected Publication:
Kapfhammer, HP; Hippius, H.
Special feature: pharmacotherapy in personality disorders.
J Personal Disord. 1998; 12(3): 277-288.
Doi: 10.1521/pedi.1998.12.3.277
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- Leading authors Med Uni Graz
- Kapfhammer Hans-Peter
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- Abstract:
- Recent epidemiological and psychobiological studies indicate that psychopharmacology is promising, even for the treatment of personality disorders. Psychotropic drugs may have positive effects on personality disorders that show a close-relationship to Axis I disorders (e.g., schizotypal personality disorder--schizophrenia simplex; avoidant personality disorder--generalized social phobia; borderline personality disorder--affective disorders, etc.). In addition, psychotropic drugs may influence certain psychopathological symptom clusters (e.g., cognitive-perceptual organization, impulsivity/aggressivity, affective instability, anxiety/inhibition) present in various disorders. Psychotropic drugs may also be indicated when psychiatric comorbidity exists. The results of clinical pharmacological studies are reviewed with reference to cluster A, B, and C personality disorders. Some guidelines can be drawn from these trials. Clinically, the use of psychotropic drugs in symptomatic crises should be considered, especially when a secondary psychiatric comorbidity exists. Pharmacotherapy is well indicated for personality disorders closely associated with Axis I disorders. Usually pharmacotherapy is short term, although in some cases long-term treatment may be promising. However, pharmacotherapy must always refer to a supportive therapeutic interaction between physician and patient.
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