Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Siebenhofer, A; Rakovac, I; Kleespies, C; Piso, B; Didjurgeit, U.
Self-management of oral anticoagulation in the elderly: rationale, design, baselines and oral anticoagulation control after one year of follow-up. A randomized controlled trial.
Thromb Haemost. 2007; 97(3):408-416
Doi: 10.1160/TH06-08-0482
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Siebenhofer-Kroitzsch Andrea
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- Abstract:
- Self-management is safe and reliable in patients with long-term oral anticoagulation (OAC). However, no study has yet assessed the safety and efficacy of OAC self-management in elderly patients with major thromboembolic and haemorrhagic complications as primary outcomes. In this multi-centre, open, randomised controlled trial, patients aged 60 years or more were randomised into the self-management group (SMG) (N = 99) or routine care group (RCG) (N = 96). We describe the rationale, design, baseline characteristics and interim analyses of oral anticoagulation control quality within the first year of follow-up. The medians of the squared international normalised ratio (INR) value deviations after six and 12 months were significantly lower in the SMG with medians of 0.16 and 0.16 compared to the RCG with medians of 0.25 and 0.25. The percentage of time within target range and the percentage of INR measurements within target range were significantly higher in the SMG versus the RCG within the first six months (medians 71% vs. 58% and 69% vs. 57%), and during the second six months of the study (75% vs. 67% and 72% vs. 57%). The numbers of all thromboembolic events requiring hospitalisation, major bleeding events, and deaths were similar in both groups. These preliminary results suggest that self-management of oral anticoagulation is safe and feasible for elderly patients willing to participate in a structured training programme.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Aged -
- Anticoagulants - administration and dosage
- Austria - administration and dosage
- Blood Coagulation - drug effects
- Drug Monitoring - methods
- Feasibility Studies - methods
- Female - methods
- Follow-Up Studies - methods
- Germany - methods
- Health Knowledge, Attitudes, Practice - methods
- Hemorrhage - chemically induced
- Humans - chemically induced
- International Normalized Ratio - chemically induced
- Male - chemically induced
- Middle Aged - chemically induced
- Patient Education as Topic - chemically induced
- Program Evaluation - chemically induced
- Research Design - chemically induced
- Self Care - chemically induced
- Thromboembolism - prevention and control
- Time Factors - prevention and control
- Find related publications in this database (Keywords)
- oral anticoagulation
- self-management
- elderly patients
- randomized controlled trial