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Selected Publication:
Holzer, P; Wachter, C; Heinemann, A; Jocic, M; Lippe, IT; Herbert, MK.
Diverse interactions of calcitonin gene related peptide and nitric oxide in the gastric and cutaneous microcirculation.
CAN J PHYSIOL PHARMACOL. 1995; 73(7): 991-994.
Doi: 10.1139/y95-138
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- Leading authors Med Uni Graz
- Holzer Peter
- Co-authors Med Uni Graz
- Heinemann Akos
- Herbert Michael K.
- Lippe Irmgard Theresia
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- Abstract:
- Calcitonin gene related peptide (CGRP) is the major mediator of afferent nerve mediated vasodilatation in the gastric mucosa and skin of the rat. Since receptors for CGRP occur on both the vascular endothelium and smooth muscle, it is conceivable that the vascular actions of CGRP involve multiple mechanisms. The vasodilator effect of rat CGRP-alpha in the rat gastric mucosa is indeed inhibited by blockage of nitric oxide (NO) synthesis, as is the gastric mucosal hyperemia in response to gastric acid challenge, which is mediated by CGRP release from afferent nerve fibres. In contrast, the vasodilator response to rat CGRP-alpha in the rat hind paw and the CGRP-mediated vasodilatation evoked by antidromic stimulation of afferent nerve fibres do not depend on the formation of NO. These data indicate that NO plays regionally different roles in the local vasodilator action of CGRP. NO is a secondary vasorelaxant messenger of CGRP in the gastric, but not in the cutaneous, microcirculation. However, this L-arginine-derived autacoid may have a role in the irritant-induced CGRP release from afferent vasodilator fibres in the skin.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcitonin Gene-Related Peptide - physiology
- Gastric Mucosa - blood supply
- Humans - blood supply
- Microcirculation - physiology
- Nitric Oxide - physiology
- Skin - blood supply
- Vasodilation - blood supply
- Find related publications in this database (Keywords)
- Calcitonin Gene Related Peptide
- Nitric Oxide
- Microcirculation
- Gastric Mucosa
- Skin
- Afferent Nerve Fibers
- Neurogenic Vasodilatation