Medizinische Universität Graz - Research portal
Selected Publication:
Urban, C; Sager, WD.
Intracranial bleeding during therapy with L-asparaginase in childhood acute lymphocytic leukemia.
Eur J Pediatr. 1981; 137(3):323-327
Doi: 10.1007/BF00443266
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Urban Ernst-Christian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Two patients developed clinical features of intracranial bleeding--which were confirmed by computerized axial tomograms--during their induction therapy for acute lymphocytic leukemia. Coagulation studies showed clotting abnormalities including severe hypofibrinogenemia. These findings most probably were related to the effect of L-asparaginase which was part of the treatment protocol. Central nervous system leukemia, intrathecal chemotherapy, cranial irradiation, extreme leukocytosis, or thrombopenia at the time of diagnosis or day of stroke did not appear to be predisposing factors in these cases.
- Find related publications in this database (using NLM MeSH Indexing)
- Asparaginase - adverse effects
- Cerebral Hemorrhage - chemically induced
- Child - chemically induced
- Child, Preschool - chemically induced
- Fibrinogen - analysis
- Humans - analysis
- Leukemia, Lymphocytic - drug therapy
- Male - drug therapy
- Tomography, X-Ray Computed - drug therapy