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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Brossner, C; Madersbacher, S; de Mare, P; Ponholzer, A; Al-Ali, B; Rauchenwald, M.
Follow-up of men obtaining a six-core versus a ten-core benign prostate biopsy 7 years previously.
World J Urol. 2005; 23(6): 419-421.
Doi: 10.1007/s00345-005-0025-3
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- Co-authors Med Uni Graz
- Mohamad Al-Ali Badereddin
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- Abstract:
- The aim of this study is to evaluate the proportion of repeat biopsies after 7 years in men with an initial benign six- or ten-core biopsy as well as the incidence of prostate cancer (PC) in the repeat biopsies. In this retrospective longitudinal study, 116 men with an elevated prostate-specific antigen (PSA) and/or a suspicious digital rectal examination (DRE) who have had a benign prostate biopsy between January 1997 and September 1997 were included. Fifty-eight men had an initial benign six-core biopsy (median PSA 7.5 ng/ml, range 0.3-67) (group A), and 58 men had an initial benign ten-core biopsy (median PSA 7.5 ng/ml, range 0.8-91.4) (group B). We analysed men with a pathological PSA velocity, a persistently elevated PSA, an abnormal DRE, a high-grade prostatic intraepithelial neoplasia or atypical adenomatous hyperplasia, or atypical small acinar proliferation as indication for rebiopsy. Furthermore, we analysed a subgroup with exclusively an increased PSA velocity (>0.75 ng/ml per year) as indication for rebiopsy. In group A, 14 men had a follow-up biopsy. In this group, follow-up biopsies yielded PC in eight men (13.8%), six (10.3%) had a negative follow-up biopsy. In contrast, in group B only four men (3.4%) had a follow-up biopsy (P=0.005). Two of them (3.4%) had PC (P=0.02), two cases (3.4%) showed a benign histology (P=0.06). The use of an extended biopsy protocol at the initial evaluation reduces the number of repeat biopsies required and decreases the number of PC detection in the follow-up biopsy cohort.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biopsy - methods
- Follow-Up Studies - methods
- Humans - methods
- Longitudinal Studies - methods
- Male - methods
- Middle Aged - methods
- Prostate - pathology
- Retrospective Studies - pathology
- Time Factors - pathology
- Find related publications in this database (Keywords)
- rebiopsies
- biopsies
- follow-up
- longitudinal
- prostate
- rebiopsy