Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Brune, K; Bickel, D; Peskar, BA.
Gastro-protective effects by extracts of Petasites hybridus: the role of inhibition of peptido-leukotriene synthesis.
Planta Med. 1993; 59(6):494-496
Doi: 10.1055/s-2006-959746
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- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
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- Abstract:
- Extracts from Petasites hybridus are in therapeutic use for more than 2000 years. They have been claimed to improve gastrointestinal pain, lung-diseases such as asthma and cough, as well as spasms of the urogenital-tract. We have investigated these claims in animal models of gastro-intestinal ulcers and confirmed that alcoholic extracts of Petasites hybridus block the ethanol-induced gastric damage and reduce small intestinal ulcerations induced in rats by indomethacin. Searching for a possible mode of action, we found that ethanolic extracts of Petasites hybridus inhibit the peptido-leukotriene biosynthesis in mouse peritoneal macrophages but leave prostaglandin biosynthesis unimpaired. We conclude that the active principle could be useful in the treatment of gastro-intestinal human diseases and that Petasites hybridus may contribute to the inhibition of calcium-dependent processes such as leukotriene biosynthesis.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anti-Ulcer Agents - pharmacology
- Cells, Cultured - pharmacology
- Gastric Mucosa - drug effects
- Intestine, Small - drug effects
- Leukotrienes - biosynthesis
- Lipoproteins - biosynthesis
- Macrophages, Peritoneal - drug effects
- Male - drug effects
- Mice - drug effects
- Plant Extracts - pharmacology
- Plants, Medicinal - chemistry
- Rats - chemistry
- Rats, Wistar - chemistry
- Find related publications in this database (Keywords)
- PETASITES HYBRIDUS
- CYTOPROTECTION
- ULCER
- PEPTIDO-LEUKOTRIENES