Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Dembinska-Kiec, A; Burchert, M; Hartwich, J; Gryglewski, R; Peskar, BA.
A neutrophil-derived NO-synthase (NOS) inhibitor.
Agents Actions Suppl. 1995; 45(15):163-168
Doi: 10.1007/978-3-0348-7346-8_23
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- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
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- Abstract:
- In the present work we have demonstrated that the low NOS activity of circulating blood neutrophils is related to an endogenous inhibitory factor. This factor inhibits constitutive NOS (cNOS) of cerebellum and inducible NOS (iNOS) of macrophages in a concentration-dependent manner. Boiling only partially diminished its activity. The inhibition of cNOS was specific, since to some degree NADPH (0.5-4 mM) and more effectively L-arginine (0.1-1 mM), but not D-arginine, reversed the inhibition.
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