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Selected Publication:
Simmet, T; Pritze, S; Thelen, KI; Peskar, BA.
Release of endothelin in the oleic acid-induced respiratory distress syndrome in rats.
Eur J Pharmacol. 1992; 211(3):319-322
Doi: 10.1016/0014-2999(92)90387-J
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- Co-authors Med Uni Graz
- Peskar Bernhard
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- Abstract:
- Rats injected intravenously with oleic acid developed pulmonary edema leading to hypoxia and hypercarbia. These changes were accompanied by an increase in immunoreactive endothelin (ir-ET) in plasma as early as 15 min after injection. At 45 min after injection plasma levels peaked at 114 +/- 19 pg/ml plasma (n = 8) and reached basal levels again after 240 min. In contrast, much larger amounts of ir-ET were found in the bronchoalveolar lavage fluid, with a peak at 120 min (2878 +/- 258 pg/lung, n = 7) preceding the maximum hypoxia observed at 180 min. In both plasma and bronchoalveolar lavage fluid samples ir-ET was characterized by reverse-phase HPLC as a mixture consisting mainly of ET-1 and smaller amounts of big ET-1, ET-2 and ET-3. In light of the biological effects of ET, the data suggest that these peptides might be of pathophysiological significance in this model of adult respiratory distress syndrome.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bronchoalveolar Lavage Fluid - chemistry
- Chromatography, High Pressure Liquid - methods
- Disease Models, Animal - methods
- Endothelins - biosynthesis
- Male - biosynthesis
- Oleic Acid - biosynthesis
- Oleic Acids - biosynthesis
- Radioimmunoassay - biosynthesis
- Rats - biosynthesis
- Rats, Inbred Strains - biosynthesis
- Respiratory Distress Syndrome, Adult - chemically induced
- Serum Albumin, Bovine - chemically induced
- Time Factors - chemically induced
- Find related publications in this database (Keywords)
- ENDOTHELIN-1
- RADIOIMMUNOASSAY
- RESPIRATORY DISTRESS SYNDROME (ADULT)
- OLEIC ACID
- BRONCHOALVEOLAR LAVAGE
- HYPOXIA