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Selected Publication:
Pallapies, D; Thelen, K; Dembinska-Kiec, A; Simmet, T; Peskar, BA.
Effect of 3-morpholinosydnonimine (SIN-1), NG-nitro-L-arginine (NNA) and NG-monomethyl-L-arginine (NMMA) on isolated anaphylactic guinea-pig hearts.
Agents Actions Suppl. 1992; 37(3):114-119
Doi: 10.1007/978-3-0348-7262-1_17
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- Co-authors Med Uni Graz
- Peskar Bernhard
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- Abstract:
- In isolated perfused ovalbumin-sensitized guinea-pig hearts modulating effects of nitric oxide (NO) on cardiac function and eicosanoid release were investigated. While the NO-donor SIN-1 exhibited a protective effect during cardiac anaphylaxis, inhibition of NO biosynthesis by NNA or NMMA aggravated anaphylactic changes of cardiac functions. Exogenous and endogenous NO seems to functionally antagonize the effects of vasoconstrictor mediators released during the anaphylactic reaction. In addition, inhibition of cysteinyl-leukotriene (cys-LT) release could contribute to the protective effect of SIN-1 observed.
- Find related publications in this database (using NLM MeSH Indexing)
- Anaphylaxis - physiopathology
- Animals - physiopathology
- Arginine - analogs and derivatives
- Coronary Circulation - drug effects
- Eicosanoids - metabolism
- Guinea Pigs - metabolism
- Heart - drug effects
- Heart Rate - drug effects
- Male - drug effects
- Molsidomine - analogs and derivatives
- Myocardium - metabolism
- Nitroarginine - metabolism
- Ovalbumin - immunology
- omega-N-Methylarginine - immunology