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Selected Publication:
Trautmann, M; Peskar, BM; Peskar, BA.
Aspirin-like drugs, ethanol-induced rat gastric injury and mucosal eicosanoid release.
Eur J Pharmacol. 1991; 201(1):53-58
Doi: 10.1016/0014-2999(91)90322-H
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- Co-authors Med Uni Graz
- Peskar Bernhard
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- Abstract:
- The effect of oral administration of various non-steroidal antiinflammatory drugs on ethanol-induced rat gastric injury and mucosal release of leukotriene C4, 6-keto-prostaglandin F1 alpha and 15-hydroxy-5,8,11,13-eicosatetraenoic acid was investigated. It was found that besides sodium salicylate and high doses of aspirin, other salicylate-type drugs, such as diflunisal, 4-aminosalicylic acid, 2,4-dihydroxybenzoic acid and methyl salicylate, and several non-acidic compounds, such as proquazone, benzydamine and paracetamol, were gastroprotective. All these drugs inhibited ex vivo leukotriene C4 formation by ethanol-stimulated gastric mucosa. However, naproxen, lonazolac, ibuprofen, gentisic acid and 5-aminosalicylic acid also inhibited leukotriene C4 formation, but were not protective. Gastroprotection was independent of 6-keto-prostaglandin F1 alpha formation. Both protective and non-protective drugs inhibited the ethanol-stimulated, but not the basal, release of 15-hydroxy-5,8,11,13-eicosatetraenoic acid. The results indicate that the differential effects of various non-steroidal antiinflammatory drugs on gastroprotection against ethanol are not correlated with specific effects on mucosal cyclooxygenase, 5-lipoxygenase or 15-lipoxygenase activity.
- Find related publications in this database (using NLM MeSH Indexing)
- 6-Ketoprostaglandin F1 alpha - metabolism
- Animals - metabolism
- Anti-Inflammatory Agents, Non-Steroidal - administration and dosage
- Aspirin - pharmacology
- Dose-Response Relationship, Drug - pharmacology
- Eicosanoids - metabolism
- Ethanol - toxicity
- Gastric Mucosa - drug effects
- Hydroxyeicosatetraenoic Acids - metabolism
- Male - metabolism
- Radioimmunoassay - metabolism
- Rats - metabolism
- Rats, Inbred Strains - metabolism
- SRS-A - metabolism
- Find related publications in this database (Keywords)
- GASTRIC INJURY (RAT)
- LEUKOTRIENE-C4
- 6-KETO-PROSTAGLANDIN-F1-ALPHA
- 15-HYDROXY-5,8,11,13-EICOSATETRAENOIC ACID
- ANTIINFLAMMATORY DRUGS (NONSTEROIDAL)
- GASTROPROTECTION