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Peskar, BM; Trautmann, M; Nowak, P; Peskar, BA.
Release of 15-hydroxy-5,8,11,13-eicosatetraenoic acid and cysteinyl-leukotrienes in carrageenin-induced inflammation: effect of non-steroidal anti-inflammatory drugs.
Agents Actions. 1991; 33(3-4):240-246 Doi: 10.1007/BF01986569
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Leading authors Med Uni Graz: Peskar Bernhard
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Abstract:: Inflammatory exudates obtained in rats after subcutaneous implantation of carrageenin-soaked sponges were found to contain relatively large amounts of 15-hydroxy-5,8,11, 13-eicosatetraenoic acid (15-HETE) and smaller amounts of cysteinyl-leukotrienes (LT) in addition to LTB4, thromboxane (TX) B2 and prostaglandin (PG)E2. Concentrations of 15-HETE and cysteinyl-LT were high 5 hours after sponge implantation and decreased significantly within 24 hours. This time-course, which is similar to that of TXB2, but differs from that of PGE2, suggests migrating leukocytes as a major source of 15-HETE and cysteinyl-LT. Aspirin, sodium salicylate, dipyrone (100 mg/kg each) and indomethacin (2 and 20 mg/kg) decrease the concentrations of cyclooxygenase products of arachidonate metabolism, but did not significantly affect levels of 15-HETE. Cysteinyl-LT were increased by 20 mg/kg indomethacin, but remained unaffected by 2 mg/kg indomethacin and by the other non-steroidal anti-inflammatory drugs (NSAID) tested. 15-HETE and cysteinyl-LT could play a mediator role in inflammation. In addition, they could modulate the release and effects of other inflammatory mediators.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Carrageenan - pharmacology; Chromatography, High Pressure Liquid - pharmacology; Cyclooxygenase Inhibitors - pharmacology; Dinoprostone - metabolism; Hydroxyeicosatetraenoic Acids - metabolism; Inflammation - chemically induced; Leukotriene B4 - metabolism; Lipoxygenase Inhibitors - pharmacology; Male - pharmacology; Radioimmunoassay - pharmacology; Rats - pharmacology; Rats, Inbred Strains - pharmacology; SRS-A - metabolism; Thromboxane B2 - metabolism