Medizinische Universität Graz - Research portal
Selected Publication:
Brune, K; Beck, WS; Geisslinger, G; Menzel-Soglowek, S; Peskar, BM; Peskar, BA.
Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition.
Experientia. 1991; 47(3):257-261
Doi: 10.1007/BF01958153
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- Co-authors Med Uni Graz
- Peskar Bernhard
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- Abstract:
- Using flurbiprofen, a chiral anti-inflammatory and analgesic 2-arylpropionic acid derivative, the enantiomers of which are not converted to each other (less than 5%) in rats or man, we obtained evidence that prostaglandin synthesis inhibition is primarily mediating the anti-inflammatory activity but prostaglandin synthesis independent mechanisms contribute to the analgesic effects. Thus, the S-form inhibited prostaglandin synthesis, inflammation and nociception in rats. The R-form had much less effect on prostaglandin synthesis and did not affect inflammation. It did, however, block nociception in rats almost as potently as the S-form. S-flurbiprofen, in contrast to the R-form, was clearly ulcerogenic in the gastrointestinal mucosa. These results indicate additional molecular mechanisms of analgesia and suggest the use of R-arylpropionic acids as analgesics.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Aspirin - analogs and derivatives
- Digestive System - drug effects
- Flurbiprofen - adverse effects
- Male - adverse effects
- Pain - drug therapy
- Prostaglandin Antagonists - therapeutic use
- Prostaglandins - biosynthesis
- Rats - biosynthesis
- Rats, Inbred Strains - biosynthesis
- Stereoisomerism - biosynthesis
- Find related publications in this database (Keywords)
- ASPIRIN-LIKE DRUGS
- FLURBIPROFEN ENANTIOMERS
- ANTIINFLAMMATORY
- ANALGESIC
- GASTROINTESTINAL TOXICITY
- PROSTAGLANDIN SYNTHESIS
- RAT