Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fitscha, P; Rauscha, F; Rogatti, W; Peskar, BA; O'Grady, J; Sinzinger, H.
13,14-dihydro-PGE1, an in-vivo metabolite of PGE1, decreases mitotic activity induced by corticosteroid administration.
Eicosanoids. 1991; 4(4): 231-233.
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- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
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- Abstract:
- PGE1 has antimitotic activity by virtue of its effect in increasing cAMP in vascular smooth muscle cells. The present study compares the effect of 13,14-dihydro-PGE1 (13,14-DH-PGE1) with PGE1 in an experimental model of stress induced by desoxycorticosterone in the rabbit. 13,14-DH-PGE1 significantly inhibited the stress-induced increase in mitotic activity, measured by autoradiography as percentage of 3H-thymidine positive cells, in all 3 abdominal aortic wall layers. Administration prior to stress was more effective than after stress, while combined administration was most effective. 13,14-DH-PGE1 exerts approximately 90% of the antimitotic activity of PGE1. It seems possible that the antimitotic activity observed after administration of intravenous PGE1 is attributable in part to 13,14-DH-PGE1.
- Find related publications in this database (using NLM MeSH Indexing)
- Alprostadil - analogs and derivatives
- Animals - analogs and derivatives
- Aorta, Abdominal - cytology
- Desoxycorticosterone - pharmacology
- Mitosis - drug effects
- Rabbits - drug effects
- Stress - drug therapy
- Thymidine - metabolism
- Find related publications in this database (Keywords)
- 13,14-DIHYDRO-PGE1
- PROSTAGLANDIN E1
- MITOTIC ACTIVITY
- RABBIT ARTERIAL WALL
- DEOXYCORTICOSTERONE ACETATE