Medizinische Universität Graz - Research portal
Selected Publication:
Hesse, WH; Rudofsky, G; Peskar, BA.
Metabolism of intravenously administered prostaglandin E1 in patients with peripheral arterial occlusive disease
Wien Klin Wochenschr. 1991; 103(18):554-557
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Peskar Bernhard
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- Abstract:
- Using high performance liquid chromatography and radioimmunoassay we have investigated the stability of prostaglandin (PG) E1 and its metabolite 13,14-dihydro-PGE1 in human plasma as well as the initial metabolism of PGE1 infused intravenously (80 micrograms/patient/hour) in patients with peripheral arterial occlusive disease. 13,14-dihydro-PGE1 degraded like PGE1 in human plasma at 37 degrees C with a half-life of several hours. During infusion of PGE1 higher plasma concentrations of the major metabolite 15-keto-13,14-dihydro-PGE1 and lower plasma levels of PGE1 and 13,14-dihydro-PGE1 were observed. The metabolite 13,14-dihydro-PGE1 is of interest, since in contrast to 15-keto-13,14-dihydro-PGE1 it is biologically active. The biosynthesis of 13,14-dihydro-PGE1 could contribute to the therapeutic efficacy of PGE1 administered intravenously in patients with peripheral arterial occlusive disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Alprostadil - administration and dosage
- Arterial Occlusive Diseases - blood
- Biotransformation - blood
- Dinoprostone - analogs and derivatives
- Female - analogs and derivatives
- Humans - analogs and derivatives
- Infusions, Intravenous - analogs and derivatives
- Male - analogs and derivatives
- Middle Aged - analogs and derivatives
- Find related publications in this database (Keywords)
- INTRAVENOUS PROSTAGLANDIN-E1 INFUSION
- 13,14-DIHYDRO-PROSTAGLANDIN-E1
- 15-KETO-13,14-DIHYDRO-PROSTAGLANDIN-E1
- PERIPHERAL ARTERIAL OCCLUSIVE DISEASE
- STABILITY OF PGE1 IN PLASMA