Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Sinzinger, H; Virgolini, I; Peskar, BA.
Response of thromboxane B2, malondialdehyde and platelet sensitivity to 3 weeks low-dose aspirin (ASA) in healthy volunteers.
Thromb Res. 1989; 53(3):261-269 Doi: 10.1016/0049-3848(89)90101-1
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Co-Autor*innen der Med Uni Graz: Peskar Bernhard
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Abstract:: To examine the effects of low-dose aspirin thromboxane B2 (TXB2), malondialdehyde (MDA) and platelet sensitivity to prostaglandin I2 (PGI2) have been measured in a total of 18 healthy volunteers. They were randomly assigned to 3 groups, 6 volunteers each, receiving either 1, 10 or 20 mg ASA orally a day for 3 weeks in a double-blind fashion. In order to assess the time course of ASA-induced changes, blood was drawn before, 1 hour and 2, 3, 5, 7, 9, 12, 14, 16 and 21 days after the first drug-intake. Serum-TXB2 was depressed time- and dose-dependently, after 1 mg daily to about 60%, after 10 mg to about 30%, after 20 mg to about 5% of controls. MDA-formation and conversion of exogenously added arachidonic acid (AA) to TXB2 also dropped significantly, (p less than 0.01), the extent depending on the ASA-dosage administered. The drop in MDA- and TXB2-values in the 3 groups correlated with r = 0.98, 0.94, 0.98, respectively. The platelet sensitivity during 20 and 10 mg ASA-administration did not change at all, whereas a significant increase (p less than 0.01) in platelet sensitivity during treatment with 1 mg ASA was observed.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Arachidonic Acid -; Arachidonic Acids - blood; Aspirin - administration and dosage; Epoprostenol - pharmacology; Female - pharmacology; Humans - pharmacology; Male - pharmacology; Malonates - blood; Malondialdehyde - blood; Platelet Aggregation - drug effects; Thromboxane B2 - blood