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Sinzinger, H; Virgolini, I; Keiler, A; Lupattelli, G; Gerakakis, A; Peskar, BA.
13,14-Dihydro-prostaglandin E1 decreases low-density lipoprotein influx into rabbit aorta.
Eur J Pharmacol. 1992; 219(1): 129-133. Doi: 10.1016/0014-2999(92)90590-Z
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Co-authors Med Uni Graz: Peskar Bernhard
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Abstract:: The effect of 4-week daily administration of 13,14-dihydro-prostaglandin E1 (13,14-DH-PGE1; 2 micrograms/kg) on LDL influx into the rabbit aortic wall was examined versus the effect of the same dose of PGE1 and sham-treatment in 108 male animals fed an 1% cholesterol supplemented diet. Treatment was started after de-endothelialization of the abdominal aorta with a Fogarty catheter. After the 1-month treatment period the animals were injected with 10 microCi 125I-low-density lipoprotein (LDL; 0.5 mg protein/ml). Uptake of the radiolabelled LDL was measured in morphologically verified endothelialized, re-endothelialized and de-endothelialized abdominal aortic segments. The LDL influx into the aorta was significantly (P less than 0.001) lower in 13,14-DH-PGE1- and PGE1-treated rabbits than in the controls. This reduction was most pronounced in re- and de-endothelialized segments. No significant difference between effect of PGE1 and of its biologically active derivative, 13,14-DH-PGE1, on arterial LDL entry was found. These data demonstrate a comparable beneficial effect of 13,14-DH-PGE1 and PGE1 on vascular wall lipid metabolism by decreasing LDL entry into the aortic wall in vivo.
Find related publications in this database (using NLM MeSH Indexing): Alprostadil - analogs and derivatives; Animals - analogs and derivatives; Aorta - chemistry; Cholesterol - analysis; Endothelium, Vascular - physiology; Humans - physiology; Lipoproteins, LDL - metabolism; Male - metabolism; Rabbits - metabolism
Find related publications in this database (Keywords): 13,14-DIHYDROPROSTAGLANDIN E1; AORTA (RABBIT); LDL (LOW DENSITY LIPOPROTEIN) INFLUX; ATHEROSCLEROSIS (EXPERIMENTAL)