Medizinische Universität Graz - Research portal
Selected Publication:
Pallapies, D; Jirmann, KU; Rademann, J; Simmet, T; Rutowski, J; Dembinska-Kiec, A; Peskar, BA.
Effect of prostaglandin E2 and 3-morpholinosydnonimine (SIN-1) on arachidonic acid metabolism in fMLP-stimulated rat neutrophils and on thrombin-induced human platelet aggregation.
Agents Actions. 1992; 36(1-2):77-82
Doi: 10.1007/BF01991232
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-authors Med Uni Graz
- Peskar Bernhard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The effects of prostaglandin (PG) E2 and the nitric oxide (NO) donor SIN-1 on leukotriene (LT) release from formyl-methionyl-leucyl-phenylalanine (fMLP) (100 nM)-stimulated rat peritoneal neutrophils (RPN) and on thrombin-induced aggregation of washed human platelets were investigated. Both PGE2 (1-100 nM) and SIN-1 (30-300 microM) inhibited release of LTB4 and cysteinyl-LT from RPN in a concentration-dependent manner. The combined effects of PGE2 and SIN-1 were not greater than expected by summation. On the other hand, the inhibitory effect of SIN-1 (0.5 or 1.0 microM) on platelet aggregation was potentiated by PGE2 (0.3-5 microM) in a concentration-dependent manner, while PGE2 alone in the concentrations used had only marginal effects. The results suggest differential regulation of platelet and leukocyte functions by the mediators PGE2 and NO, which could be relevant for various physiological and pathophysiological conditions.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arachidonic Acid - metabolism
- Dinoprostone - pharmacology
- Exudates and Transudates - cytology
- Humans - cytology
- Leukotrienes - biosynthesis
- Male - biosynthesis
- Molsidomine - analogs and derivatives
- N-Formylmethionine Leucyl-Phenylalanine - pharmacology
- Neutrophils - drug effects
- Platelet Aggregation - drug effects
- Platelet Aggregation Inhibitors - pharmacology
- Rats - pharmacology
- Rats, Wistar - pharmacology
- Thrombin - pharmacology