Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Simmet, T; Wittenberg, HR; Peskar, BA.
Modulation of eicosanoid release from anaphylactic guinea-pig heart with 5-benzoyl-a-methyl-2-thiophene acetic acid (tiaprofenic acid).
Arch Int Pharmacodyn Ther. 1985; 278(2):207-214
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- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
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- Abstract:
- The effects of infusion of the non-steroidal anti-inflammatory drugs (NSAID), tiaprofenic acid (2.2 micrograms/min or 10.0 micrograms/min) and indomethacin (1.0 microgram/min) on the release of leukotriene (LT) C4-like immunoreactivity, thromboxane (TX) B2 and 6-keto-prostaglandin (PG) F1 alpha from isolated perfused anaphylactic guinea-pig hearts were investigated. Tiaprofenic acid at both concentrations used significantly inhibited anaphylactic release of TXB2 and 6-keto-PGF1 alpha as did indomethacin (1.0 microgram/min) which was, however, about ten times more potent in this respect. Release of immunoreactive LTC4-like material was not influenced by the lower concentration of tiaprofenic acid used (2.2 micrograms/min), but significantly enhanced by the higher concentration (10.0 micrograms/min). Thus, the effect of tiaprofenic acid on eicosanoid release by the anaphylactic heart is very similar to that of indomethacin without any differential inhibition of TXB2 or 6-keto-PGF1 alpha formation.
- Find related publications in this database (using NLM MeSH Indexing)
- 6-Ketoprostaglandin F1 alpha - metabolism
- Anaphylaxis - metabolism
- Animals - metabolism
- Anti-Inflammatory Agents - pharmacology
- Eicosanoic Acids - metabolism
- Guinea Pigs - metabolism
- Indomethacin - pharmacology
- Male - pharmacology
- Myocardium - metabolism
- Propionates - pharmacology
- Propionic Acids - pharmacology
- SRS-A - pharmacology
- Thromboxane B2 - metabolism