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Polterauer, P; Sinzinger, H; Peskar, BA.
The influence of irradiation on the biological half-life of prostacyclin in plasma of patients with gastrointestinal cancer.
Br J Exp Pathol. 1987; 68(5): 637-642.
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Co-authors Med Uni Graz: Peskar Bernhard
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Abstract:: In seven patients suffering from inoperable pancreatic cancer and in 14 patients with inoperable colonic cancer the half-life (T/2) of prostaglandin (PG)I2 in plasma in vitro has been determined before and at various intervals after irradiation. No significant difference of PGI2-T/2 could be observed either before irradiation, at the end of the irradiation period or 3 and 6 weeks after the last irradiation. Thus irradiation does not appear to interfere with the degradation of PGI2-T/2 in plasma. In patients with inoperable pancreatic and colonic cancer the PGI2-T/2 was not significantly different to that of the PGI2-T/2 of controls. Thus, a shortening of PGI2-T/2 is not a common feature in tumour patients. Hyperaggregation promoting seeding of metastases is not influenced by irradiation via the particular parameter of the PG-system.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Colonic Neoplasms - blood; Epoprostenol - blood; Female - blood; Gamma Rays - blood; Half-Life - blood; Humans - blood; Male - blood; Middle Aged - blood; Pancreatic Neoplasms - blood; Radiation Effects - blood; Time Factors - blood