Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Brune, K; Peskar, BA.
Paracetamol does not potentiate the acetylsalicylate inhibition of prostaglandin release from macrophages.
Eur J Pharmacol. 1980; 68(3):365-367
Doi: 10.1016/0014-2999(80)90534-8
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- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
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- Abstract:
- Prostaglandin (PGE2 and PGI2) synthesis can be stimulated in macrophages by the tumour promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) and inhibited by acetylsalicyclic acid (IC50 = 8.2 x 10(-6) M) and paracetamol (IC50 = 1.9 x 10(-4) M). When mixture of both drugs were tested only an additive effect was observed. This result is in contrast to recent reports describing both potentiation of acetylsalicylate-induced PG synthesis inhibition and enhancement of PG production by paracetamol.
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