Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Leithner, C; Sinzinger, H; Stummvoll, HK; Klein, K; Silberbauer, K; Peskar, BA.
Enhanced 6-oxo-PGF1 alpha levels in plasma during hemodialysis.
Prostaglandins Med. 1980; 5(6):425-427
Doi: 10.1016/0161-4630(80)90066-X
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- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
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- Abstract:
- The activation of platelets due to foreign surface interaction is a well known fact. Earlier, we found an increase of circulating platelet microaggregates (method of Wu and Hoak) during hemodialysis. Since this phenomenon might cause a PGI2-release by lung and/or vascular tissue, we studied the plasma 6-oxo-PGF 1 alpha-levels in 6 patients during hemodialysis. We found an initial increase of plasma 6-oxo-PGF 1 alpha. Coincidently, hypoxemia, fall in platelet and lekocyte count and a decrease in platelet count ratio were observed. An effect of heparin was excluded in a control group. The findings support the hypothesis that PGI2 acts as a defense mechanism against platelet deposition on vascular wall by a temporary increased synthesis which could be monitored by a temporarily enhanced plasma 6-oxo-PGF 1 alpha-level during the initial phase of hemodialysis.
- Find related publications in this database (using NLM MeSH Indexing)
- 6-Ketoprostaglandin F1 alpha -
- Adolescent -
- Adult -
- Chronic Disease -
- Female -
- Humans -
- Leukocyte Count -
- Male -
- Middle Aged -
- Oxygen - blood
- Platelet Aggregation - blood
- Platelet Count - blood
- Prostaglandins F - blood
- Renal Dialysis - blood
- Uremia - therapy