Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

Anhut, H; Jackisch, R; Peskar, BA.
Thromboxane B2 release and 3H-noradrenaline accumulation by a synaptosomal fraction of rat brain.
Pol J Pharmacol Pharm. 1979; 31(4): 381-386.
Web of Science PubMed Google Scholar

Co-authors Med Uni Graz: Peskar Bernhard
Altmetrics:
Dimensions Citations:
Plum Analytics:
Abstract:: Release of thromboxane B2 (TXB2) and accumulation of 3H-noradrenaline (3H-NA) by a synaptosomal fraction of rat brain were investigated. TXB2 release was temperature-dependent and was inhibited by three different TX-synthetase inhibitors: imidazole, 9,11-azoprosta-5,13-dieonic acid (AZO) and 11,9-epoxyiminoprosta-5,13-dionic acid (EPI). While high concentrations of imidazole decreased the 3H-NA accumulation in the synaptosomes significantly, AZO and EPI were ineffective. The results show that TX synthesis is not essential for 3H-NA uptake and the effect of imidazole in 3H-NA accumulation is unrelated to its inhibitory effect on the enzyme TX-synthetase.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Brain - metabolism; Norepinephrine - metabolism; Rats - metabolism; Synaptosomes - metabolism; Thromboxane B2 - metabolism; Thromboxane-A Synthase - antagonists and inhibitors; Thromboxanes - metabolism