Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Anhut, H; Jackisch, R; Peskar, BA.
Thromboxane B2 release and 3H-noradrenaline accumulation by a synaptosomal fraction of rat brain.
Pol J Pharmacol Pharm. 1979; 31(4): 381-386.
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- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
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- Abstract:
- Release of thromboxane B2 (TXB2) and accumulation of 3H-noradrenaline (3H-NA) by a synaptosomal fraction of rat brain were investigated. TXB2 release was temperature-dependent and was inhibited by three different TX-synthetase inhibitors: imidazole, 9,11-azoprosta-5,13-dieonic acid (AZO) and 11,9-epoxyiminoprosta-5,13-dionic acid (EPI). While high concentrations of imidazole decreased the 3H-NA accumulation in the synaptosomes significantly, AZO and EPI were ineffective. The results show that TX synthesis is not essential for 3H-NA uptake and the effect of imidazole in 3H-NA accumulation is unrelated to its inhibitory effect on the enzyme TX-synthetase.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain - metabolism
- Norepinephrine - metabolism
- Rats - metabolism
- Synaptosomes - metabolism
- Thromboxane B2 - metabolism
- Thromboxane-A Synthase - antagonists and inhibitors
- Thromboxanes - metabolism