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Selected Publication:
Dembinska-Kiec, A; Simmet, T; Peskar, BA.
Release and vasoconstrictor effect of leukotriene C-like immunoreactive material in the anaphylactic guinea-pig mesenteric vascular bed.
Eur J Pharmacol. 1984; 101(3-4):259-262
Doi: 10.1016/0014-2999(84)90166-3
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- Co-authors Med Uni Graz
- Peskar Bernhard
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- Abstract:
- Antigen challenge of sensitized isolated guinea-pig mesentery perfused under constant pressure resulted in a significant flow reduction, which was paralleled by the release of leukotriene (LT)C4-like immunoreactivity into the perfusates. The lipoxygenase inhibitor quercetin inhibited the release of immunoreactive LTC4 and simultaneously abolished the antigen-induced mesenteric flow reduction. Mesenteric flow reduction was also observed after injection of exogenous LTC4. The results demonstrate that LTC4 is a constrictor of the mesenteric vascular bed and that endogenous LTC4-like immunoreactive material is a mediator of anaphylactic vasoconstriction in the guinea-pig mesentery.
- Find related publications in this database (using NLM MeSH Indexing)
- Anaphylaxis - physiopathology
- Animals - physiopathology
- Guinea Pigs - physiopathology
- Male - physiopathology
- Mesentery - blood supply
- Quercetin - pharmacology
- Radioimmunoassay - pharmacology
- SRS-A - metabolism
- Splanchnic Circulation - drug effects
- Time Factors - drug effects
- Vasoconstriction - drug effects