Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fitscha, P; Keiler, A; O'Grady, J; Peskar, BA; Sinzinger, H.
Isradipine decreases arterial thrombogenicity in rabbits. A morphometric and radioisotopic study.
Thromb Res. 1994; 74(3):175-183
Doi: 10.1016/0049-3848(94)90106-6
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
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- Abstract:
- The effect of isradipine, a calcium antagonist, on aortic and iliac wall thrombogenicity was examined in rabbits. After one week of dosing, the abdominal aortic and iliac artery endothelium was abraded using a Fogarthy catheter. One group of animals (n = 8) was dosed for one week with isradipine 0.3 mg/kg. A second group of animals received 10 mg acetylsalicylic acid (ASA)/kg daily in addition, while a third group received the vehicle only. Finally, a fourth group of animals (n = 8) was treated with ASA only. The percentage denuded surface covered with contact (unspread) platelets decreased significantly (p < 0.01) from 14.7 +/- 2.0 to 9.3 +/- 2.1 (6.2 +/- 0.8 to 3.7 +/- 0.4). The amount of contact and spread platelets was diminished from 84.9 +/- 5.6 to 71.4 +/- 4.4 (91.8 +/- 5.3 to 75.2 +/- 4.6). Platelet thrombi decreased from 7.4 +/- 0.9 to 4.6 +/- 1.4 (9.4 +/- 1.9 to 5.2 +/- 0.7) in the aortic and the iliac artery, respectively. In-platelet deposition decreased by 39.9 and 41.9%. Concomitant ASA therapy not only abolished the effect of isradipine but enhanced thrombogenicity, probably as a result of almost complete blockade of vascular PGI2-production.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Aorta - drug effects
- Endothelium, Vascular - drug effects
- Epoprostenol - biosynthesis
- Iliac Artery - drug effects
- Indium Radioisotopes - diagnostic use
- Isradipine - pharmacology
- Male - pharmacology
- Rabbits - pharmacology
- Thrombosis - pathology
- Find related publications in this database (Keywords)
- ISRADIPINE
- THROMBOGENICITY
- IN-111-OXINE
- PLATELETS
- CALCIUM ANTAGONIST