Medizinische Universität Graz - Research portal
Selected Publication:
Lembeck, F; Beubler, E.
Inhibition of PGE1 induced intestinal secretion by the synthetic enkephalin analogue FK 33-824.
Naunyn Schmiedebergs Arch Pharmacol. 1979; 308(3):261-264
Doi: 10.1007/BF00501391
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- Co-authors Med Uni Graz
- Beubler Eckhard
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- Abstract:
- 1. The effects of the enkephalin analogue, FK 33-824 were compared with those of morphine and naloxone on the prostaglandin E1-induced increase in intestinal fluid volume and unanaesthetized and pithed rats. 2. FK 33-824 inhibits the prostaglandin E1-induced increase in intestinal fluid volume both in unanaesthetized and pithed rats. 3. Naloxone abolished the inhibitory effect of FK 33-824 in both experimental models. 4. It can be concluded from the experiments in pithed rats that the inhibitory effect of FK 33-824, like that of morphine, on prostaglandin E1-induced secretion is caused by a peripheral action. 5. It is assumed that endogenous enkephalins protect against prostaglandin-mediated loss of fluid into the gut lumen. This protective effect can be mimicked by an enkephalin analogue and blocked by naloxone.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Endorphins - pharmacology
- Enkephalins - pharmacology
- Female - pharmacology
- Half-Life - pharmacology
- Intestinal Mucosa - secretion
- Intestines - drug effects
- Morphine - pharmacology
- Naloxone - pharmacology
- Prostaglandins E - antagonists and inhibitors
- Rats - antagonists and inhibitors