Medizinische Universität Graz - Research portal
Selected Publication:
Lücker, PW; Beubler, E; Kukovetz, WR; Ritter, W.
Retention time and concentration in human skin of bifonazole and clotrimazole.
Dermatologica. 1984; 169 Suppl 1(5): 51-55.
Doi: 10.1159/000249639
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-authors Med Uni Graz
- Beubler Eckhard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The retention time and the extent of penetration in human skin of [14C] labelled bifonazole in comparison to [14C] labelled clotrimazole were investigated in 8 healthy volunteers. In the course of the investigation the backs of the volunteers were treated half with bifonazole, half with clotrimazole which remained on the skin for 24 h. From 24 to 168 h after the administration the skin was stripped with the tear-off strip technique. Three dermal layers of different depth were examined. The results of the examinations revealed, that the quantity of bifonazole that penetrated into the skin was more than twice as high as the quantity of clotrimazole. However, the half-lives and the mean retention times of bifonazole and clotrimazole were nearly similar to each other.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Topical -
- Adult -
- Antifungal Agents - metabolism
- Clotrimazole - metabolism
- Half-Life - metabolism
- Humans - metabolism
- Imidazoles - metabolism
- Male - metabolism
- Skin - metabolism
- Skin Absorption - metabolism