Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kukovetz, WR; Beubler, E; Kreuzig, F; Moritz, AJ; Nirnberger, G; Werner-Breitenecker, L.
Bioavailability and pharmacokinetics of D-penicillamine.
J Rheumatol. 1983; 10(1):90-94
Doi: 10.1016/0315-0860(83)90038-1
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- Co-Autor*innen der Med Uni Graz
- Beubler Eckhard
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- Abstract:
- The absolute and the relative bioavailability of D-penicillamine, available from different dosage forms and products, was studied in 10 healthy volunteers. Plasma levels and urine excretion of D-penicillamine were determined up to 8 h after administration by high performance liquid chromatography after intravenous administration of 250 mg and after oral administration of 250 mg (2 products) and 150 mg (1 product) D-penicillamine. The absolute bioavailability on oral administration was 50-70%. No statistical difference was found between the relative bioavailabilities of the different dosage forms tested.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adult -
- Biological Availability -
- Chromatography, High Pressure Liquid -
- Female -
- Humans -
- Injections, Intravenous -
- Kinetics -
- Male -
- Penicillamine - administration and dosage