Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Ratzenhofer, M; Gamse, R; Höfler, H; Auböck, L; Popper, H; Pohl, P; Lembeck, F.
Substance P in the argentaffin carcinoid of the caecum: biochemical and biological characterization.
VIRCHOWS ARCH A PATH ANAT HIS. 1981; 392(1): 21-31.
Doi: 10.1007/BF00430545
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Lembeck Fred
- Popper Helmuth
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- Abstract:
- An argentaffin carcinoid tumour of the caecum which contained serotonin (167 micrograms/g) and consisted predominantly of EC1-cells, was analysed for the presence of peptides using immunohistochemical, biochemical and pharmacological methods. A very high content of 3.9 micrograms/g of immunoreactive substance P was found. The distribution of cells staining positively for substance P matched that of cells containing serotonin. While some immunoreactive somatostatin (3.2 ng/g) was present in the tumour, neurotensin, glucagon, gastrin, and motilin were not found. Part of the substance P immunoreactivity measured most likely represents authentic substance P: it behaved like substance P in two chromatographic systems and in two bioassays, and its activity on the guinea pig ileum was abolished by specific tachyphylaxis towards substance P.
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