Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hutterer, GC; Karakiewicz, PI; Zippe, C; Lüdecke, G; Boman, H; Sanchez-Carbayo, M; Casella, R; Mian, C; Friedrich, MG; Eissa, S; Akaza, H; Serretta, V; Hedelin, H; Rupesh, R; Miyanaga, N; Sagalowsky, AI; Perrotte, P; Lotan, Y; Marberger, MJ; Shariat, SF.
Urinary cytology and nuclear matrix protein 22 in the detection of bladder cancer recurrence other than transitional cell carcinoma.
BJU Int. 2008; 101(5):561-565
Doi: 10.1111/j.1464-410X.2007.07352.x
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- Leading authors Med Uni Graz
- Hutterer Georg
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- Abstract:
- OBJECTIVE: To assess the value of nuclear matrix protein-22 (NMP22), compared with urinary cytology, in predicting the recurrence of bladder cancer that is not transitional cell carcinoma (non-TCC). PATIENTS AND METHODS: We tested the sensitivity, specificity and the predictive accuracy of NMP22 in the context of non-TCC bladder cancer recurrence, and compared it to the performance of urinary cytology. The study group comprised 2687 patients with history of non-muscle-invasive bladder cancer from 10 centres across four continents. RESULTS: The mean patient age was 64.8 years and 75.4% were men; of all patients, 513 (19.1%) had positive urinary cytology, 906 (33.7%) had a positive NMP22 test (>or=10 units/mL) and 80 (3.0%) had non-TCC recurrence. Most of these, i.e. 60 (75%), were stage >or=T2. The sensitivity and specificity of urinary cytology were, respectively, 20.0% and 94.8%, vs 77.5% and 81.8% for NMP22 of >or=10 units/mL. The predictive accuracy of urinary cytology was 57.5%, vs 87.1% for NMP22 >or= 10 units/mL. A combined model that included dichotomized NMP22 and urinary cytology was 85.3% accurate. CONCLUSION: The ability of a NMP22 level of >or=10 units/mL to predict non-TCC recurrence was better than that of urinary cytology, suggesting that NMP22 might have a role in the surveillance of patients at risk of non-TCC recurrence.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Squamous Cell - pathology
- Child -
- Cohort Studies -
- Female -
- Humans -
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local - diagnosis
- Nuclear Proteins - metabolism
- Predictive Value of Tests -
- Prognosis -
- Retrospective Studies -
- Risk Factors -
- Sensitivity and Specificity -
- Tumor Markers, Biological - metabolism
- Urinary Bladder Neoplasms - diagnosis
- Find related publications in this database (Keywords)
- bladder cancer
- disease recurrence
- NMP22
- prediction
- squamous cell carcinoma
- transitional cell carcinoma