Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Bastian, PJ; Hutterer, GC; Shariat, SF; Rogers, CG; Palapattu, GS; Lotan, Y; Vazina, A; Amiel, GE; Gupta, A; Sagalowsky, AI; Lerner, SP; Schoenberg, MP; Karakiewicz, PI; Bladder Cancer Research Consortium.
Macroscopic, but not microscopic, perivesical fat invasion at radical cystectomy is an adverse predictor of recurrence and survival.
BJU Int. 2008; 101(4):450-454
Doi: 10.1111/j.1464-410X.2007.07213.x
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- Co-authors Med Uni Graz
- Hutterer Georg
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- Abstract:
- OBJECTIVE: To examine whether the presence of microscopic (pT3a) or macroscopic (pT3b) disease worsens the prognosis relative to pT2 disease at radical cystectomy, as the prognostic significance of pT3a vs pT3b perivesical fat invasion (pT3) is controversial. PATIENTS AND METHODS: In all, 242 patients with pT3 disease (pT3a in 88, pT3b in 121) had radical cystectomy and bilateral pelvic lymphadenectomy for transitional cell carcinoma of the urinary bladder; they were compared with 172 who had organ-confined muscle-invasive disease (pT2). For the analyses we used univariable and multivariable Cox regression models of recurrence and cancer-specific survival, adjusted for age, tumour grade, lymphovascular invasion and the presence of lymph node metastases. RESULTS: In multivariable analyses, microscopic perivesical fat extension (pT3a) was not associated with higher recurrence (P = 0.3) or the mortality rate (P = 0.06) vs pT2 disease. Conversely, the presence of deep perivesical fat extension (pT3b) was associated with 1.8 times the rate of recurrence (P = 0.002) and with twice the rate of death (P = 0.001) vs pT2 disease. CONCLUSION: These findings imply that a detailed assessment of the cystectomy specimen for the presence of microscopic perivesical fat invasion might not be necessary, as the presence of pT3a disease has no strong effect on recurrence or mortality. Moreover, patients with pT3a disease might not require more aggressive therapy than their counterparts with pT2 disease. However, further validation of our data is required.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - pathology
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Transitional Cell - mortality
- Cohort Studies -
- Cystectomy -
- Female -
- Follow-Up Studies -
- Humans -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Invasiveness - pathology
- Neoplasm Recurrence, Local - pathology
- Neoplasm Staging - methods
- Prognosis -
- Survival Analysis -
- Treatment Outcome -
- Urinary Bladder Neoplasms - mortality
- Find related publications in this database (Keywords)
- bladder cancer
- cystectomy
- recurrence
- stage
- survival