Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bhojani, N; Jeldres, C; Patard, JJ; Perrotte, P; Suardi, N; Hutterer, G; Patenaude, F; Oudard, S; Karakiewicz, PI.
Toxicities associated with the administration of sorafenib, sunitinib, and temsirolimus and their management in patients with metastatic renal cell carcinoma.
Eur Urol. 2008; 53(5):917-930
Doi: 10.1016/j.eururo.2007.11.037
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Hutterer Georg
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- Abstract:
- OBJECTIVE: To provide a systematic review of the side effects associated with sorafenib, sunitinib, and temsirolimus and to provide an outline of possible preventive or therapeutic measures. METHODS: We performed a PubMed-based systematic review of side effects associated with the three agents and relied on product monographs and prescribing information to provide an outline of treatments aimed at reducing these toxicities. RESULTS: Side effects range from <1% to 72%. Grade 3/4 side effects are less common and range from <1% to 13% for sorafenib, <1% to 16% for sunitinib, and 1% to 20% for temsirolimus. Overall, sunitinib causes the most grade 3/4 side effects and sorafenib causes the fewest grade 3/4 side effects, although head-to-head trials are required to compare safety profiles of all three kinase inhibitors. Virtually all side effects can be managed effectively. CONCLUSION: Prevention, recognition, and prompt management of side effects are of key importance and avoid unnecessary dose reductions, which may undermine treatment efficacy.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - administration and dosage
- Benzenesulfonates - administration and dosage
- Carcinoma, Renal Cell - drug therapy
- Dose-Response Relationship, Drug -
- Drug Toxicity - diagnosis
- Humans -
- Indoles - administration and dosage
- Kidney Neoplasms - drug therapy
- Prognosis -
- Pyridines - administration and dosage
- Pyrroles - administration and dosage
- Receptors, Vascular Endothelial Growth Factor -
- Sirolimus - administration and dosage
- Find related publications in this database (Keywords)
- side effects
- sorafenib
- sunitinib
- temsirolimus