Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Walz, J; Gallina, A; Hutterer, G; Perrotte, P; Shariat, SF; Graefen, M; McCormack, M; Bénard, F; Valiquette, L; Saad, F; Karakiewicz, PI.
Accuracy of life tables in predicting overall survival in candidates for radiotherapy for prostate cancer.
Int J Radiat Oncol Biol Phys. 2007; 69(1): 88-94.
Doi: 10.1016/j.ijrobp.2007.02.022
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PubMed
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- Co-authors Med Uni Graz
- Hutterer Georg
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- Abstract:
- PURPOSE: To test the accuracy of life tables (LTs) in predicting survival in men treated with radiotherapy for localized prostate cancer. METHODS AND MATERIALS: We selected the records of 3,176 patients treated with radiotherapy and who had no clinical evidence of disease relapse. Life table-derived life expectancy (LE) was defined for every individual using a population-specific LT. Age, Charlson Comorbidity Index (CCI), and LT-derived LE were then used as predictors of overall mortality in Cox regression models. Predictive accuracy (PA) was estimated with the Harrell's concordance index and was internally validated with 200 bootstrap resamples. RESULTS: The actuarial median survival was 4.7 years (mean, 6.4 years). At radiotherapy, median age was 70.6 years, median CCI was 2, and median LT-derived LE was 12 years. All variables were statistically significant predictors of overall mortality (all p values <0.001). Age (PA, 60.2%), CCI (PA, 60.1%), and LT-derived LE (PA, 60.2%) were equally accurate. Finally, when age and CCI were combined (PA, 63.2%), both variables provided more accurate mortality predictions than either variable alone (all p values = 0.01). CONCLUSIONS: Life tables have a limited ability to predict LE in patients treated with radiotherapy for prostate cancer. We, therefore, recommend the use of multivariate prognostic models that integrate several variables, such as at least age and comorbidities, to estimate LE. This might help to improve LE estimation during prostate cancer treatment decision making.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aged -
- Aged, 80 and over -
- Analysis of Variance -
- Humans -
- Life Expectancy -
- Life Tables -
- Male -
- Middle Aged -
- Proportional Hazards Models -
- Prostatic Neoplasms - mortality
- Quebec - mortality
- Survival Analysis - mortality
- Find related publications in this database (Keywords)
- prostate cancer
- life tables
- radiotherapy
- life expectancy
- comorbidity