Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gibbons, S; Moser, E; Hausmann, S; Stavri, M; Smith, E; Clennett, C.
An anti-staphylococcal acylphloroglucinol from Hypericum foliosum.
Phytochemistry. 2005; 66(12): 1472-1475.
Doi: 10.1016/j.phytochem.2005.04.024
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Moser Elisabeth
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- Abstract:
- An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2''',3'''-epoxy-3'''-methyl-butyl]-2-[2''-methyl-butanoyl]-4-[3'-methyl-2''-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 microg/ml.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Bacterial Agents - isolation and purification
- Epoxy Compounds - isolation and purification
- Hypericum - chemistry
- Inhibitory Concentration 50 - chemistry
- Magnetic Resonance Spectroscopy - chemistry
- Microbial Sensitivity Tests - chemistry
- Molecular Structure - chemistry
- Phloroglucinol - analogs and derivatives
- Plant Components, Aerial - chemistry
- Plant Extracts - isolation and purification
- Staphylococcus aureus - drug effects
- Find related publications in this database (Keywords)
- Hypericum foliosum
- acylphloroglucinol
- Guttiferae
- antibacterial
- MRSA
- MDR
- Staphylococcus aureus