Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gibbons, S; Moser, E; Kaatz, GW.
Catechin gallates inhibit multidrug resistance (MDR) in Staphylococcus aureus.
Planta Med. 2004; 70(12): 1240-1242.
Doi: 10.1055/s-2004-835860
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Moser Elisabeth
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- Abstract:
- Epicatechin gallate (1) and epigallocatechin gallate (2) were evaluated for their antibacterial and efflux inhibitory activity against a wild-type and three multidrug-resistant (MDR) strains of Staphylococcus aureus. Compound 2 was more active than 1 based on minimum inhibitory concentrations (MICs; 32-64 versus 64->512 microg/mL, respectively). When incorporated into the growth medium at 20 microg/mL, both compounds exhibited a four-fold potentiation of the activity of norfloxacin against a norfloxacin-resistant strain of S. aureus overexpressing the NorA multidrug efflux pump. Against this strain 1 was moderately more potent than 2 as an inhibitor of ethidium efflux, but at < or = 20 microM both compounds paradoxically stimulated efflux. This phenomenon has not been encountered previously in the analysis of inhibitors of multidrug efflux.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Bacterial Agents - administration and dosage
- Catechin - administration and dosage
- Drug Resistance, Multiple - administration and dosage
- Humans - administration and dosage
- Microbial Sensitivity Tests - administration and dosage
- Phytotherapy - administration and dosage
- Plants, Medicinal - administration and dosage
- Staphylococcus aureus - drug effects