Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Urban, C; Rosen, G; Huvos, AG; Caparros, B; Cacavio, A; Nirenberg, A.
Chemotherapy of malignant fibrous histiocytoma of bone. A report of five cases.
Cancer. 1983; 51(5):795-802
Doi: 10.1002/1097-0142(19830301)51:5<795::AID-CNCR2820510508>3.0.CO;2-M
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Urban Ernst-Christian
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Five patients with evaluable malignant fibrous histiocytoma (MFH) of bone (three with primary tumor and two with primary tumor and metastatic disease) were treated with preoperative chemotherapy including high dose methotrexate (HDMTX) with citrovorum factor rescue (CFR) as is used for patients with osteogenic sarcoma. All five patients demonstrated a clinical response to chemotherapy. Three of four patients who underwent surgery had complete responses and one patient had greater than 90% tumor necrosis as documented by histologic examination of the resected primary tumor. All four patients who underwent surgery following preoperative chemotherapy are surviving free of disease from one to six years from the start of treatment; chemotherapy was discontinued after six to 11 months in these patients. The median disease-free survival time is 31.5 months. This study demonstrates the effectiveness of chemotherapy in MFH of bone, and in particular the effectiveness of HDMTX with CFR which caused measurable responses in all patients while receiving this therapy as a single agent.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Bone Neoplasms - drug therapy
- Drug Therapy, Combination - drug therapy
- Female - drug therapy
- Follow-Up Studies - drug therapy
- Histiocytoma, Benign Fibrous - drug therapy
- Humans - drug therapy
- Leucovorin - therapeutic use
- Male - therapeutic use
- Methotrexate - administration and dosage
- Neoplasm Metastasis - administration and dosage